Yale scientists successfully repair injured spinal cords using the patients’ own stem cells

Researchers from Yale have reported preliminary success in repairing spinal cord injuries in patients using intravenous injections of bone marrow derived from the patients own stem cells (MSCs).

Substantial improvements in key functions like the ability to walk, or to use their hands were found within weeks of stem cell injection for over half of the patients studied and no substantial side effects were reported. The patients had non-penetrating spinal cord injuries, in many cases from falls or minor trauma, several weeks prior to implantation of the stem cells. Their symptoms involved loss of motor function and coordination, sensory loss, as well as bowel and bladder dysfunction.

The stem cells were prepared from the patients’ own bone marrow, by a culture protocol that took a few weeks in a specialized cell processing center. The cells were injected intravenously in this series, with each patient serving as their own control and there were no placebo controls. Yale scientists Jeffery D. Kocsis and Stephen G. Waxman were the senior authors of the study.

It was carried out with investigators at Sapporo Medical University in Japan, with the results published last month in the Journal of Clinical Neurology and Neurosurgery. Kocsis and Waxman stress that additional studies will be needed to confirm the results of this preliminary, unblinded trial. They also stress that this could take years.

“Similar results with stem cells in patients with stroke increases our confidence that this approach may be clinically useful,” noted Kocsis. “This clinical study is the culmination of extensive preclinical laboratory work using MSCs between Yale and Sapporo colleagues over many years.”

“The idea that we may be able to restore function after injury to the brain and spinal cord using the patient’s own stem cells has intrigued us for years,” Waxman said. “Now we have a hint, in humans, that it may be possible.”

Source: YaleNews

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